Bullous Pemphigoid (BP) is the most common immunobullous skin disease.
This was a descriptive cross-sectional study of electronic health records data at a specialist dermatology clinic at Tygerberg Hospital in the Western Cape. Patients presenting during a predefined 5-year period with a clinicopathologic diagnosis of BP were included.
The final sample comprised 54 cases of BP. The median age at diagnosis was 71.0 years, and 64.8% were female. Eighty per cent had at least one chronic medical condition at the time of BP diagnosis. The most common comorbidities were hypertension (63.0%), diabetes mellitus (33.3%) and strokes (24.1%). Twenty-eight per cent had been diagnosed with at least one neurological comorbidity at the time of BP diagnosis. Patients experienced a median delay of 45 days (interquartile range: 21.0-90.0 days) between onset of symptoms and presentation to dermatology.
This is the first study reporting co-morbidities in patients with BP in sub-Saharan Africa. Despite the high burden of disease due to physical injury in the study setting, no patients with BP had a history of traumatic brain injury. This suggests the possibility that the association between BP and neurologic disorders is limited to stroke, epilepsy, and neurodegenerative diseases. Future prospective cohort studies are indicated to further investigate the results of this study.
To describe neurologic and other comorbidities in patients presenting with BP at a tertiary hospital in South Africa. This research in South Africa, a lower-middle-income country, seeks to address knowledge gaps, utilize data, and advance the field of dermatology.
Bullous pemphigoid (BP) is the most common autoimmune bullous skin disease. It mainly affects individuals over the age of 65 years, and typically presents with tense bullae on an erythematous, urticarial base.
The annual incidence of BP is approximately 2.4–21.7 per million across most regions of the world, including France, Switzerland, Germany, among others.
Systematic review evidence suggests a statistically significant association between BP and neurologic diseases, specifically stroke, Parkinson’s disease, dementia, epilepsy, and multiple sclerosis.
The relationship between BP and other comorbidities has also been studied. Meta-analysis shows no association between BP and ischaemic heart disease.
South Africa is an upper-middle-income country,
The aim of this study was to describe the comorbidities in patients presenting to a tertiary level dermatology clinic with BP in Cape Town, South Africa. To the best of our knowledge, this is the first such study from sub-Saharan Africa.
This descriptive cross-sectional study involved a retrospective review of medical records at Tygerberg Hospital (Cape Town, South Africa). Patients were included if they presented between 01 January 2016 until 31 December 2020 with a final diagnosis of BP made, based on both clinical and histopathologic findings. There were no age or sex restrictions. Patients were excluded if the diagnosis was not supported by histopathologic findings, including direct immunofluorescence.
The following variables are reported: demographic characteristics (age and sex), time between onset of symptoms and diagnosis of BP, and pre-existing comorbidities at the time of BP diagnosis. For continuous variables with normal distributions, averages are presented as means with standard deviations (s.d). For skewed distributions, averages are presented as medians with interquartile ranges (IQRs).
The Health Research Ethics Committee (HREC) of Stellenbosch University granted ethical clearance for this study (Project ID: 24771; Ethics Reference Number: U22/03/160). As this is a retrospective study, a waiver of informed consent was deemed appropriate. Confidentiality was maintained through data that was anonymised at the point of data capture.
A total of 57 potentially eligible patients were identified from medical records. Three cases were excluded because the diagnosis of BP in each was subsequently revised to bullous systemic lupus erythematosus, bullous scabies and epidermolysis bullosa acquisita, respectively. The demographic characteristics of the 54 remaining patients included in the final analysis are shown in
Baseline characteristics of patients with bullous pemphigoid.
| Characteristic | Value |
|||
|---|---|---|---|---|
| Median | IRQ | % | ||
| Age in years at diagnosis | 71.0 | 65.3–82.0 | - | - |
| < 20 | - | - | 0 | 0.0 |
| 20–49 | - | - | 2 | 3.7 |
| 50–59 | - | - | 7 | 13.0 |
| 60–69 | - | - | 13 | 24.1 |
| 70–79 | - | - | 12 | 22.2 |
| ≥ 80 | - | - | 20 | 37.0 |
| Male | - | - | 19 | 35.2 |
| Female | - | - | 35 | 64.8 |
| Duration of symptoms prior to diagnosis | 45 | 21–90 | - | - |
IQR, interquartile range.
Forty-three patients (79.6%) had at least one chronic disease at the time of BP diagnosis. The most prevalent pre-existing systemic diseases were hypertension (
Pre-existing comorbidities at time of bullous pemphigoid diagnosis (
| Disease | Patients with BP |
|
|---|---|---|
| % | ||
| Neurological disease | 15 | 27.8 |
| Stroke | 13 | 24.1 |
| Dementia | 1 | 1.9 |
| Epilepsy | 1 | 1.9 |
| Parkinsons | 0 | 0.0 |
| Multiple sclerosis | 0 | 0.0 |
| Cardiovascular | 41 | 76.8 |
| Hypertension | 34 | 63.0 |
| Dyslipidemia | 7 | 13.0 |
| Ischaemic heart disease | 0 | 0.0 |
| Arrhythmia | 0 | 0.0 |
| Endocrinopathies | 20 | 37.0 |
| Diabetes mellitus | 18 | 33.3 |
| Hypothyroidism | 2 | 3.7 |
| Psychiatric diagnoses | 4 | 7.4 |
| Depression | 2 | 3.7 |
| Other mood disorders | 2 | 3.7 |
| Other | ||
| COPD | 4 | 7.4 |
| Overweight or obese (BMI > 25) | 2 | 3.7 |
| Malignancies | 3 | 5.6 |
| Renal disease | 2 | 3.7 |
| HIV | 3 | 5.6 |
BP, bullous pemphigoid; COPD, chronic obstructive pulmonary disease; BMI, body mass index; HIV, human immunodeficiency virus.
This descriptive, cross-sectional study reports comorbidities in patients presenting to a tertiary hospital dermatology clinic with BP over a 5-year period. Firstly, in terms of baseline characteristics, we found that most of our patients were female (64.8%) and the median age at presentation was 71.0 years. Secondly, we found that 81.5% of patients had at least one chronic medical condition at the time of BP diagnosis. The most common preceding chronic medical conditions were hypertension (63.0%), type 2 diabetes mellitus (33.3%) and stroke (24.1%). Thirdly, we found that 27.8% of our sample had a pre-existing neurological disease, of which stroke was overwhelmingly the most common. No patients had a history of TBI. Lastly, although not a primary objective of the study, it was notable that there was a median delay of 45 days (IQR: 21.0–90.0 days) between onset of symptoms and presentation to dermatology.
The female predominance and advanced age of patients with BP in our study are in keeping with observations in other settings. In our study 35 of 54 participants (64.8%) were female, equating to a female-to-male ratio of 1.8. Similarly, in other studies, female-to-male ratios range from 1.04–5.1.
Sixty-three per cent of BP patients in this study had a preceding diagnosis of hypertension. This is higher than the proportion of BP patients with hypertension reported in other settings, for example Finland (44.0%), Korea (32.1%) and Turkey (43.4%).
A third of BP patients in this study had a preceding diagnosis of type 2 diabetes mellitus. As this study did not have a control group, it is not possible to ascertain whether there is a correlation between BP and type 2 diabetes. However, it is possible that the high prevalence of type 2 diabetes in this study simply mirrors the high prevalence of diabetes in older adults in South Africa. According to the results of a systematic review and meta-analysis, the prevalence of type 2 diabetes in South Africa across all age groups is 15.25% (95% confidence interval [CI]: 11.07–19.95).
In all 15 patients with BP (27.8%) had a previously diagnosed neurological disease. Most of these (13 of 15) were strokes. The prevalence of stroke in our study is higher than the purported prevalence in South Africa of 1.29% (95% CI: 0.83–1.75).
The proportion of BP patients with neurological disease in our study (27.8%) is lower than reported in several other studies for example from Finland (46%), France (36%), and Portugal (55.8%).
South Africa has an exceptionally high burden of physical injuries, including interpersonal violence and road traffic accidents.
Although not one of our primary objectives, we observed that patients experienced considerable delay in diagnosis. The median waiting time was 45 days, with half of the cohort waiting between 21 days and 90 days. Given the increasing prevalence and significant morbidity and mortality associated with BP, the reasons for this delay should be investigated and addressed to improve the quality of care.
This study had several limitations. Firstly, as this was a retrospective study that relied on medical records, some comorbidities may have been missed. Detailed records of chronic medications used at the time of onset of BP were also not consistently available. Secondly, as this was an uncontrolled study, relative risks could not be calculated. Thirdly, records only extended to patients seen in the dermatology outpatient’s clinic. Patients who were diagnosed via inpatient referrals who did not attend follow-up appointments might have been missed. Fourthly, our sample consisted of only 54 patients from a single province in South Africa. Although, as discussed above, BP is a rare disease with an incidence of approximately 2.4–21.7 per million, selection bias remains a concern. Without more data, limited inferences can be made about comorbidities in sub-Saharan Africans with BP in general.
Results from this study found that most patients (80%) presenting to a tertiary hospital dermatology clinic with BP over a 5-year period had at least one comorbidity. The most common comorbidities are hypertension (63%), type 2 diabetes mellitus (33%), and stroke (24%). Despite the high burden of injuries in South Africa, no patients with BP had a history of TBI. Patients experienced considerable delay in diagnosis, with a median wait of 45 days (IQR: 21.0–90.0 days) between the onset of symptoms and presentation to dermatology. This is the first study reporting on comorbidities in patients with BP in sub-Saharan Africa. Future prospective cohort studies are indicated to further investigate these associations, as well as to evaluate potentially implicated drugs. Data from other referral centres in sub-Saharan Africa would improve the generalisability of findings. The reasons for diagnostic delay also warrant further study.
The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.
C.P.S. and N.A.G. posed the research question. C.P.S. was in charge of the methodology (including ethics approval), formal analysis and investigation. The original draft was compiled by C.P.S, and he also analysed and captured the data. N.A.G. assisted with the methodology of this study. She reviewed and edited the drafts, and was also a co-author in this article. W.I.V. helped with the conceptualisation of this study. He reviewed the article and fulfilled a supervisor position for this project.
No publicly available datasets. The data that support the findings of this study are not openly available because of reasons of sensitivity (e.g. human data). This decision was made to protect the privacy and confidentiality of the individuals involved in the research, ensuring compliance with ethical standards and regulations regarding the handling of sensitive information.
Raw data are kept according to the safety measures stipulated in the approved protocol by Health Research Ethics Committee (HREC). Data posed in this article are the only data approved for public.
The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors and the publisher.