Therapeutic efficacy of topical glycerol in atrophic rhinitis: A case series analysis

Abstract

Introduction: Managing atrophic rhinitis (AR) poses ongoing challenges, with no clear consensus on the optimal treatment approach. Recent exploration into the utilisation of biomaterials in rhinology presents a promising avenue for research. Among these biomaterials, glycerol stands out for its multifaceted benefits in postoperative sinonasal care. Its properties include improved lubrication, preservation of mucosal moisture and facilitation of platelet adhesion and aggregation, thus promoting efficient wound healing processes. The purpose of this case series was to assess the impact of glycerol applied topically to the nasal mucosal in individuals diagnosed with secondary AR.

Patients’ presentation: We identified three patients with secondary AR.

Management and outcome: Topical glycerol was administered daily, with twice daily saline irrigations. Follow-up for these patients was conducted in our outpatient department. Subjective and objective endoscopic measurements of nasal features improved markedly at 6 weeks follow-up.

Conclusion: The application of topical glycerol has demonstrated both subjective and objective efficacy in alleviating sinonasal symptoms associated with AR. It effectively prevents excessive mucosal loss, reduces crusting and enhances ventilation in affected patients.

Contribution: Managing AR has historically presented challenges. However, the introduction of topical glycerol application offers a novel, cost-effective and widely accessible option for addressing mucosal changes in the sinonasal region.